| Applications: |
ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.073ng/mL |
| Detection Limit: |
0.156-10ng/mL |
| Short Description: |
This GRIA4 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
Gria4 |
| Gene ID: |
14802 |
| Uniprot ID: |
GRIA4_MOUSE |
| Sample Type: |
tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-611 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-837 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis. Phosphorylated at Ser-862 by PRKCG.phosphorylation increases plasma membrane-associated GRI4 expression. |
| Function | Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. |
| Protein Name | Glutamate Receptor 4Glur-4Glur4Ampa-Selective Glutamate Receptor 4Glur-DGlutamate Receptor Ionotropic - Ampa 4Glua4 |
| Database Links | Reactome: R-MMU-399710Reactome: -MMU-399719Reactome: -MMU-416993Reactome: -MMU-438066Reactome: -MMU-8849932 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell MembraneCell ProjectionDendriteInteraction With Cnih2Cnih3 And Prkcg Promotes Cell Surface Expression |
| Alternative ELISA Names | Glutamate Receptor 4 ELISA kitGlur-4 ELISA kitGlur4 ELISA kitAmpa-Selective Glutamate Receptor 4 ELISA kitGlur-D ELISA kitGlutamate Receptor Ionotropic - Ampa 4 ELISA kitGlua4 ELISA kitGria4 ELISA kitGlur4 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
