Mouse GP39 (Glycoprotein 39, Cartilage) Sandwich ELISA Kit Ready-To-Use (STJE0015624)

SKU:
STJE0015624

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Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.054ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This GP39 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Chi3l1
Gene ID: 12654
Uniprot ID: CH3L1_MOUSE
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma or other biological fluids.
Tissue Specificity Detected in lung in pulmonary macrophages and alveolar type 2 cells and in bronchoalveolar lavage (BAL) fluids. Expressed in mammary tumor cells (at protein level). Expressed in lung. Not detected in non-inflammatory colon.
Post Translational Modifications
Function Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.
Protein Name Chitinase-3-Like Protein 1
Brp39 Protein
Breast Regression Protein 39
Cartilage Glycoprotein 39
Cgp-39
Gp-39
Database Links Reactome: R-MMU-6798695
Cellular Localisation Secreted
Extracellular Space
Cytoplasm
Endoplasmic Reticulum
Detected In Bronchoalveolar Lavage (Bal) Fluids
Localizes Mainly To Endoplasmic Reticulum When Overexpressed In Cells
With Some Protein Also Detected Throughout The Cytoplasm
Alternative ELISA Names Chitinase-3-Like Protein 1 ELISA kit
Brp39 Protein ELISA kit
Breast Regression Protein 39 ELISA kit
Cartilage Glycoprotein 39 ELISA kit
Cgp-39 ELISA kit
Gp-39 ELISA kit
Chi3l1 ELISA kit
Brp39 ELISA kit
Chil1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance