• Mouse FGFR2 (Fibroblast Growth Factor Receptor 2) Sandwich ELISA Kit Ready-To-Use (STJE0015296)

Mouse FGFR2 (Fibroblast Growth Factor Receptor 2) Sandwich ELISA Kit Ready-To-Use (STJE0015296)

SKU:
STJE0015296

Shipping:
Free Shipping
Current Stock:
Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 30.1pg/mL
Detection Limit: 78.125-5000pg/mL
Short Description: This FGFR2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Fgfr2
Gene ID: 14183
Uniprot ID: FGFR2_MOUSE
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity
Post Translational Modifications Autophosphorylated. Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes receptor dimerization and autophosphorylation on tyrosine residues. Autophosphorylation occurs in trans between the two FGFR molecules present in the dimer. N-glycosylated in the endoplasmic reticulum. The N-glycan chains undergo further maturation to an Endo H-resistant form in the Golgi apparatus. Ubiquitinated. FGFR2 is rapidly ubiquitinated after autophosphorylation, leading to internalization and degradation. Subject to degradation both in lysosomes and by the proteasome.
Function Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.
Protein Name Fibroblast Growth Factor Receptor 2
Fgfr-2
Keratinocyte Growth Factor Receptor
Kgfr
Cd Antigen Cd332
Database Links Reactome: R-MMU-109704
Reactome: -MMU-1257604
Reactome: -MMU-190375
Reactome: -MMU-190377
Reactome: -MMU-5654221
Reactome: -MMU-5654695
Reactome: -MMU-5654699
Reactome: -MMU-5654700
Reactome: -MMU-5654727
Reactome: -MMU-5673001
Reactome: -MMU-6811558
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Golgi Apparatus
Cytoplasmic Vesicle
Detected On Osteoblast Plasma Membrane Lipid Rafts
After Ligand Binding
The Activated Receptor Is Rapidly Internalized And Degraded
Alternative ELISA Names Fibroblast Growth Factor Receptor 2 ELISA kit
Fgfr-2 ELISA kit
Keratinocyte Growth Factor Receptor ELISA kit
Kgfr ELISA kit
Cd Antigen Cd332 ELISA kit
Fgfr2 ELISA kit
Bek ELISA kit
Ect1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance