| Applications: |
ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
25pg/mL |
| Detection Limit: |
78.1-5000pg/mL |
| Short Description: |
This DPP9 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
Dpp9 |
| Gene ID: |
224897 |
| Uniprot ID: |
DPP9_MOUSE |
| Sample Type: |
tissue homogenates or other biological fluids. |
| Tissue Specificity | Detected in kidney, skin, brain, thymus and liver (at protein level). |
| Post Translational Modifications | |
| Function | Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8. Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation. The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8.however, neither NLRP1 nor CARD8 are bona fide substrates of DPP9, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition. |
| Protein Name | Dipeptidyl Peptidase 9Dp9Dipeptidyl Peptidase IxDpp IxDipeptidyl Peptidase-Like Protein 9Dplp9 |
| Database Links | |
| Cellular Localisation | CytoplasmCytosol |
| Alternative ELISA Names | Dipeptidyl Peptidase 9 ELISA kitDp9 ELISA kitDipeptidyl Peptidase Ix ELISA kitDpp Ix ELISA kitDipeptidyl Peptidase-Like Protein 9 ELISA kitDplp9 ELISA kitDpp9 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
