| Applications: |
ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.047ng/mL |
| Detection Limit: |
0.156-10ng/mL |
| Short Description: |
This DNMT3B Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
Dnmt3b |
| Gene ID: |
13436 |
| Uniprot ID: |
DNM3B_MOUSE |
| Sample Type: |
tissue homogenates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | Sumoylated. Citrullinated by PADI4. |
| Function | Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Functions as a transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells. |
| Protein Name | DnaCytosine-5-Methyltransferase 3bDnmt3bDna Methyltransferase MmuiiibDna Mtase MmuiiibM.mmuiiib |
| Database Links | Reactome: R-MMU-212300Reactome: -MMU-4655427 |
| Cellular Localisation | NucleusAccumulates In The Major Satellite Repeats At Pericentric Heterochromatin |
| Alternative ELISA Names | Dna ELISA kitCytosine-5-Methyltransferase 3b ELISA kitDnmt3b ELISA kitDna Methyltransferase Mmuiiib ELISA kitDna Mtase Mmuiiib ELISA kitM.mmuiiib ELISA kitDnmt3b ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
