• Mouse DMT1 (Divalent Metal Transporter 1) Sandwich ELISA Kit (STJE0008467)

Mouse DMT1 (Divalent Metal Transporter 1) Sandwich ELISA Kit (STJE0008467)

SKU:
STJE0008467

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Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.109ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This DMT1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Slc11a2
Gene ID: 18174
Uniprot ID: NRAM2_MOUSE
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Isoform 1: Abundantly expressed in erythroid precursor cells (at protein level). Isoform 2: Expressed in duodenum (at protein level).
Post Translational Modifications Ubiquitinated by WWP2. N-glycosylated.
Function Proton-coupled metal ion symporter operating with a proton to metal ion stoichiometry of 1:1. Selectively transports various divalent metal cations, in decreasing affinity: Cd(2+) > Fe(2+) > Co(2+), Mn(2+) >> Zn(2+), Ni(2+), VO(2+). Essential for maintenance of iron homeostasis by modulating intestinal absorption of dietary Fe(2+) and TF-associated endosomal Fe(2+) transport in erythroid precursors and other cells. Enables Fe(2+) and Mn(2+) ion entry into mitochondria, and is thus expected to promote mitochondrial heme synthesis, iron-sulfur cluster biogenesis and antioxidant defense. Can mediate uncoupled fluxes of either protons or metal ions.
Protein Name Natural Resistance-Associated Macrophage Protein 2
Nramp 2
Divalent Cation Transporter 1
Divalent Metal Transporter 1
Dmt-1
Solute Carrier Family 11 Member 2
Database Links Reactome: R-MMU-425410
Reactome: -MMU-917937
Cellular Localisation Isoform 1: Golgi Apparatus
Trans-Golgi Network Membrane
Multi-Pass Membrane Protein
Early Endosome Membrane
Recycling Endosome Membrane
Cell Membrane
Isoform 2: Golgi Apparatus
Late Endosome Membrane
Lysosome Membrane
Apical Cell Membrane
Mitochondrion Outer Membrane
Extracellular Vesicle Membrane
Alternative ELISA Names Natural Resistance-Associated Macrophage Protein 2 ELISA kit
Nramp 2 ELISA kit
Divalent Cation Transporter 1 ELISA kit
Divalent Metal Transporter 1 ELISA kit
Dmt-1 ELISA kit
Solute Carrier Family 11 Member 2 ELISA kit
Slc11a2 ELISA kit
Dct1 ELISA kit
Dmt1 ELISA kit
Nramp2 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance