| Applications: |
ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.109ng/mL |
| Detection Limit: |
0.312-20ng/mL |
| Short Description: |
This DMT1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
Slc11a2 |
| Gene ID: |
18174 |
| Uniprot ID: |
NRAM2_MOUSE |
| Sample Type: |
tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | Isoform 1: Abundantly expressed in erythroid precursor cells (at protein level). Isoform 2: Expressed in duodenum (at protein level). |
| Post Translational Modifications | Ubiquitinated by WWP2. N-glycosylated. |
| Function | Proton-coupled metal ion symporter operating with a proton to metal ion stoichiometry of 1:1. Selectively transports various divalent metal cations, in decreasing affinity: Cd(2+) > Fe(2+) > Co(2+), Mn(2+) >> Zn(2+), Ni(2+), VO(2+). Essential for maintenance of iron homeostasis by modulating intestinal absorption of dietary Fe(2+) and TF-associated endosomal Fe(2+) transport in erythroid precursors and other cells. Enables Fe(2+) and Mn(2+) ion entry into mitochondria, and is thus expected to promote mitochondrial heme synthesis, iron-sulfur cluster biogenesis and antioxidant defense. Can mediate uncoupled fluxes of either protons or metal ions. |
| Protein Name | Natural Resistance-Associated Macrophage Protein 2Nramp 2Divalent Cation Transporter 1Divalent Metal Transporter 1Dmt-1Solute Carrier Family 11 Member 2 |
| Database Links | Reactome: R-MMU-425410Reactome: -MMU-917937 |
| Cellular Localisation | Isoform 1: Golgi ApparatusTrans-Golgi Network MembraneMulti-Pass Membrane ProteinEarly Endosome MembraneRecycling Endosome MembraneCell MembraneIsoform 2: Golgi ApparatusLate Endosome MembraneLysosome MembraneApical Cell MembraneMitochondrion Outer MembraneExtracellular Vesicle Membrane |
| Alternative ELISA Names | Natural Resistance-Associated Macrophage Protein 2 ELISA kitNramp 2 ELISA kitDivalent Cation Transporter 1 ELISA kitDivalent Metal Transporter 1 ELISA kitDmt-1 ELISA kitSolute Carrier Family 11 Member 2 ELISA kitSlc11a2 ELISA kitDct1 ELISA kitDmt1 ELISA kitNramp2 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
