| Applications: |
ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.047ng/mL |
| Detection Limit: |
0.156-10ng/mL |
| Short Description: |
This DDR1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
Ddr1 |
| Gene ID: |
12305 |
| Uniprot ID: |
DDR1_MOUSE |
| Sample Type: |
serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
| Tissue Specificity | Detected in the cochlea and the organ of Corti in the inner ear. Isoform 1 is predominant and is expressed in developing embryo and adult brain. Isoform 2 is expressed in various epithelial cells. |
| Post Translational Modifications | Autophosphorylated in response to fibrillar collagen binding. |
| Function | Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing, but also tumor cell invasion. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Phosphorylates PTPN11. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing. |
| Protein Name | Epithelial Discoidin Domain-Containing Receptor 1Epithelial Discoidin Domain Receptor 1Cd167 Antigen-Like Family Member ACell Adhesion KinaseDiscoidin Receptor Tyrosine KinaseProtein-Tyrosine Kinase Mpk-6Tyrosine Kinase DdrTyrosine-Protein Kinase CakCd Antigen Cd167a |
| Database Links | Reactome: R-MMU-3000171 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative ELISA Names | Epithelial Discoidin Domain-Containing Receptor 1 ELISA kitEpithelial Discoidin Domain Receptor 1 ELISA kitCd167 Antigen-Like Family Member A ELISA kitCell Adhesion Kinase ELISA kitDiscoidin Receptor Tyrosine Kinase ELISA kitProtein-Tyrosine Kinase Mpk-6 ELISA kitTyrosine Kinase Ddr ELISA kitTyrosine-Protein Kinase Cak ELISA kitCd Antigen Cd167a ELISA kitDdr1 ELISA kitCak ELISA kitEddr1 ELISA kitMpk6 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
