• Mouse CX3CL1/Fractalkine protein (Recombinant) (C-His) (STJP001386)

Mouse CX3CL1/Fractalkine protein (Recombinant) (C-His) (STJP001386)

SKU:
STJP001386

£63.50 - £223.50
Current Stock:
Host: HEK293 cells
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Mouse CX3CL1/Fractalkine-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Gene Symbol: Cx3cl1
Gene ID: 20312
Uniprot ID: X3CL1_MOUSE
Immunogen: Recombinant Mouse CX3CL1/Fractalkine Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln25-Arg337) of mouse CX3CL1/Fractalkine (Accession #NP_033168.2) fused with a 6×His tag at the C-terminus.
Post Translational Modifications A soluble short 80 kDa form may be released by proteolytic cleavage from the long membrane-anchored form.
Function Chemokine that acts as a ligand for both CX3CR1 and integrins ITGAV:ITGB3 and ITGA4:ITGB1. The CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis. Regulates leukocyte adhesion and migration processes at the endothelium. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1. Processed fractalkine: The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. Fractalkine: The membrane-bound form promotes adhesion of those leukocytes to endothelial cells.
Protein Name Fractalkine
Fk
Abcd-3
C-X3-C Motif Chemokine 1
Cx3c Membrane-Anchored Chemokine
Neurotactin
Small-Inducible Cytokine D1 Cleaved Into - Processed Fractalkine
Database Links Reactome: R-MMU-380108
Reactome: -MMU-418594
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Processed Fractalkine: Secreted
Alternative Protein Names Fractalkine protein
Fk protein
Abcd-3 protein
C-X3-C Motif Chemokine 1 protein
Cx3c Membrane-Anchored Chemokine protein
Neurotactin protein
Small-Inducible Cytokine D1 Cleaved Into - Processed Fractalkine protein
Cx3cl1 protein
Cx3c protein
Fkn protein
Scyd1 protein

Information sourced from Uniprot.org

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