• Mouse CRN (Corin) Sandwich ELISA Kit Ready-To-Use (STJE0014533)

Mouse CRN (Corin) Sandwich ELISA Kit Ready-To-Use (STJE0014533)

SKU:
STJE0014533

Shipping:
Free Shipping
Current Stock:
Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 6.7pg/mL
Detection Limit: 15.6-1000pg/mL
Short Description: This CRN Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Corin
Gene ID: 53419
Uniprot ID: CORIN_MOUSE
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma or other biological fluids.
Tissue Specificity Highly expressed in heart. Also expressed in pregnant uterus.
Post Translational Modifications N-glycosylated.required for processing and activation. Activated through proteolytic processing by a trypsin-like protease.cleaved into a N-terminal propeptide and an activated corin protease fragment. Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment is produced by cleavage by ADAM10. Cleavage by ADAM10 to produce soluble 180 kDa soluble fragment takes place after the transmembrane region and before FZ 1. A disulfide bond links the activated corin protease fragment and the N-terminal propeptide. The disulfide bond also links the activated corin protease fragment with Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment.
Function Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide.
Protein Name Atrial Natriuretic Peptide-Converting Enzyme
Corin
Low Density Lipoprotein Receptor-Related Protein 4
Pro-Anp-Converting Enzyme Cleaved Into - Atrial Natriuretic Peptide-Converting Enzyme - N-Terminal Propeptide - Atrial Natriuretic Peptide-Converting Enzyme - Activated Protease Fragment - Atrial Natriuretic Peptide-Converting Enzyme - 180 Kda Soluble Fragment
Database Links Reactome: R-MMU-5578768
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Atrial Natriuretic Peptide-Converting Enzyme
180 Kda Soluble Fragment: Secreted
Soluble Form Produced Following Cleavage By Adam10
Alternative ELISA Names Atrial Natriuretic Peptide-Converting Enzyme ELISA kit
Corin ELISA kit
Low Density Lipoprotein Receptor-Related Protein 4 ELISA kit
Pro-Anp-Converting Enzyme Cleaved Into - Atrial Natriuretic Peptide-Converting Enzyme - N-Terminal Propeptide - Atrial Natriuretic Peptide-Converting Enzyme - Activated Protease Fragment - Atrial Natriuretic Peptide-Converting Enzyme - 180 Kda Soluble Fragment ELISA kit
Corin ELISA kit
Crn ELISA kit
Lrp4 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance