| Applications: |
ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
6.7pg/mL |
| Detection Limit: |
15.6-1000pg/mL |
| Short Description: |
This CRN Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
3 hrs |
| Gene Symbol: |
Corin |
| Gene ID: |
53419 |
| Uniprot ID: |
CORIN_MOUSE |
| Immunogen Region: |
Ready-To-Use |
| Sample Type: |
serum, plasma or other biological fluids. |
| Tissue Specificity | Highly expressed in heart. Also expressed in pregnant uterus. |
| Post Translational Modifications | N-glycosylated.required for processing and activation. Activated through proteolytic processing by a trypsin-like protease.cleaved into a N-terminal propeptide and an activated corin protease fragment. Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment is produced by cleavage by ADAM10. Cleavage by ADAM10 to produce soluble 180 kDa soluble fragment takes place after the transmembrane region and before FZ 1. A disulfide bond links the activated corin protease fragment and the N-terminal propeptide. The disulfide bond also links the activated corin protease fragment with Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment. |
| Function | Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide. |
| Protein Name | Atrial Natriuretic Peptide-Converting EnzymeCorinLow Density Lipoprotein Receptor-Related Protein 4Pro-Anp-Converting Enzyme Cleaved Into - Atrial Natriuretic Peptide-Converting Enzyme - N-Terminal Propeptide - Atrial Natriuretic Peptide-Converting Enzyme - Activated Protease Fragment - Atrial Natriuretic Peptide-Converting Enzyme - 180 Kda Soluble Fragment |
| Database Links | Reactome: R-MMU-5578768 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinAtrial Natriuretic Peptide-Converting Enzyme180 Kda Soluble Fragment: SecretedSoluble Form Produced Following Cleavage By Adam10 |
| Alternative ELISA Names | Atrial Natriuretic Peptide-Converting Enzyme ELISA kitCorin ELISA kitLow Density Lipoprotein Receptor-Related Protein 4 ELISA kitPro-Anp-Converting Enzyme Cleaved Into - Atrial Natriuretic Peptide-Converting Enzyme - N-Terminal Propeptide - Atrial Natriuretic Peptide-Converting Enzyme - Activated Protease Fragment - Atrial Natriuretic Peptide-Converting Enzyme - 180 Kda Soluble Fragment ELISA kitCorin ELISA kitCrn ELISA kitLrp4 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
