Host: |
HEK293 cells |
Reactivity: |
Mouse |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Recombinant-Mouse CD24-C-hFc protein was developed from hek293 cells and has a target region of C-hFc. For use in research applications. |
Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
Immunoreactivity: |
Measured by its binding ability in a functional ELISA. Immobilized Human CD24 at 2 Mu g/mL (100 Mu L/well) can bind Human Siglec10 with a linear range of 40-900ng/mL. |
Gene Symbol: |
Cd24 |
Gene ID: |
12484 |
Uniprot ID: |
CD24_MOUSE |
Immunogen: |
Recombinant Mouse CD24 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asn27-Gly53) of mouse CD24 (Accession #NP_033976.1) fused with a hFc tag at the C-terminus. |
Post Translational Modifications | The identity of the N- and O-linked polysaccharides is not reported in PubMed:1530634. The O-linked polysaccharides on Ser-30, Ser-41, Ser-43, and Thr-51 are probably the mucin type linked to GalNAc. |
Function | May have a pivotal role in cell differentiation of different cell types. May have a specific role in early thymocyte development. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity. |
Protein Name | Signal Transducer Cd24Lymphocyte Antigen 52Ly-52M1/69-J11d Heat Stable AntigenHsaNectadrinR13-AgX62 Heat Stable AntigenCd Antigen Cd24 |
Cellular Localisation | Cell MembraneLipid-AnchorGpi-Anchor |
Alternative Protein Names | Signal Transducer Cd24 proteinLymphocyte Antigen 52 proteinLy-52 proteinM1/69-J11d Heat Stable Antigen proteinHsa proteinNectadrin proteinR13-Ag proteinX62 Heat Stable Antigen proteinCd Antigen Cd24 proteinCd24 proteinCd24a proteinLy-52 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance