| Applications: |
ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.58ng/mL |
| Detection Limit: |
1.56-100ng/mL |
| Short Description: |
This CAPN1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
3 hrs |
| Gene Symbol: |
Capn1 |
| Gene ID: |
12333 |
| Uniprot ID: |
CAN1_MOUSE |
| Immunogen Region: |
Ready-To-Use |
| Sample Type: |
tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | Undergoes calcium-induced successive autoproteolytic cleavages that generate a membrane-bound 78 kDa active form and an intracellular 75 kDa active form. Calpastatin reduces with high efficiency the transition from 78 kDa to 75 kDa calpain forms. |
| Function | Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-388' and 'His-410'. Cleaves and activates caspase-7 (CASP7). |
| Protein Name | Calpain-1 Catalytic SubunitCalcium-Activated Neutral Proteinase 1Canp 1Calpain Mu-TypeCalpain-1 Large SubunitMicromolar-CalpainMucanp |
| Database Links | Reactome: R-MMU-1474228Reactome: -MMU-6798695 |
| Cellular Localisation | CytoplasmCell MembraneTranslocates To The Plasma Membrane Upon Ca(2+) Binding |
| Alternative ELISA Names | Calpain-1 Catalytic Subunit ELISA kitCalcium-Activated Neutral Proteinase 1 ELISA kitCanp 1 ELISA kitCalpain Mu-Type ELISA kitCalpain-1 Large Subunit ELISA kitMicromolar-Calpain ELISA kitMucanp ELISA kitCapn1 ELISA kitCanp1 ELISA kitCapa1 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
