| Applications: |
ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.115ng/mL |
| Detection Limit: |
0.312-20ng/mL |
| Short Description: |
This CACNa1C Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
3 hrs |
| Gene Symbol: |
Cacna1c |
| Gene ID: |
12288 |
| Uniprot ID: |
CAC1C_MOUSE |
| Immunogen Region: |
Ready-To-Use |
| Sample Type: |
tissue homogenates or other biological fluids. |
| Tissue Specificity | Detected in embryonic heart. Detected in retina in rod bipolar cells. Detected in tibialis artery (at protein level). Detected in smooth muscle cells from tibialis artery and in mesenteric artery. High expression in heart, followed by brain and spinal cord. |
| Post Translational Modifications | Phosphorylation by PKA at Ser-1897 activates the channel. Elevated levels of blood glucose lead to increased phosphorylation by PKA. |
| Function | Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable). |
| Protein Name | Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1cCalcium Channel - L Type - Alpha-1 Polypeptide - Isoform 1 - Cardiac MuscleMelc-CcMouse Brain Class CMbcVoltage-Gated Calcium Channel Subunit Alpha Cav1.2 |
| Database Links | Reactome: R-MMU-422356Reactome: -MMU-5576892Reactome: -MMU-5576893 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinSarcolemmaPerikaryonPostsynaptic Density MembraneCell ProjectionDendriteT-TubuleColocalizes With Ryanodine Receptors In Distinct Clusters At The Junctional MembraneWhere The Sarcolemma And The Sarcoplasmic Reticulum Are In Close ContactThe Interaction Between Rrad And Cacnb2 Promotes The Expression Of Cacna1c At The Cell MembraneLocalized In T-TubulesAs Shown In Serca2-Knockout Cardiomyocytes |
| Alternative ELISA Names | Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1c ELISA kitCalcium Channel - L Type - Alpha-1 Polypeptide - Isoform 1 - Cardiac Muscle ELISA kitMelc-Cc ELISA kitMouse Brain Class C ELISA kitMbc ELISA kitVoltage-Gated Calcium Channel Subunit Alpha Cav1.2 ELISA kitCacna1c ELISA kitCach2 ELISA kitCacn2 ELISA kitCacnl1a1 ELISA kitCchl1a1 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
