| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | <0.1 EU/Mu g |
| Immunoreactivity: | Measured by its binding ability in a functional ELISA. Immobilized Mouse PD-L2 at 10 Mu g/mL (100 Mu L/well) can bind Biotinylated Mouse PD-1 with a linear range of 0.019-4.4 Mu g/mL. |
| Gene Symbol: | Pdcd1lg2 |
| Gene ID: | 58205 |
| Uniprot ID: | PD1L2_MOUSE |
| Immunogen Region: | Leu20-Arg219 |
| Immunogen: | Recombinant Mouse B7-DC/PD-L2/CD273 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu20-Arg219) of mouse B7-DC/PD-L2/CD273 (Accession #NP_067371.1) fused with and a 6×His tag at the C-terminus. |
| Immunogen Sequence: | LFTVTAPKEVYTVDVGSSVS LECDFDRRECTELEGIRASL QKVENDTSLQSERATLLEEQ LPLGKALFHIPSVQVRDSGQ YRCLVICGAAWDYKYLTVKV KASYMRIDTRILEVPGTGEV QLTCQARGYPLAEVSWQNVS VPANTSHIRTPEGLYQVTSV LRLKPQPSRNFSCMFWNAHM KELTSAIIDPLSRMEPKVPR |
| Function | Involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production. |
| Protein Name | Programmed Cell Death 1 Ligand 2Pd-1 Ligand 2Pd-L2Pdcd1 Ligand 2Programmed Death Ligand 2Butyrophilin B7-DcB7-DcCd Antigen Cd273 |
| Database Links | Reactome: R-MMU-389948 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Programmed Cell Death 1 Ligand 2 proteinPd-1 Ligand 2 proteinPd-L2 proteinPdcd1 Ligand 2 proteinProgrammed Death Ligand 2 proteinButyrophilin B7-Dc proteinB7-Dc proteinCd Antigen Cd273 proteinPdcd1lg2 proteinB7dc proteinBtdc proteinCd273 proteinPdl2 protein |
Information sourced from Uniprot.org