• Mouse APPBP2 (Amyloid Beta Precursor Protein Binding Protein 2) Sandwich ELISA Kit Ready-To-Use (STJE0013649)

Mouse APPBP2 (Amyloid Beta Precursor Protein Binding Protein 2) Sandwich ELISA Kit Ready-To-Use (STJE0013649)

SKU:
STJE0013649

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Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.115ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This APPBP2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Appbp2
Gene ID: 66884
Uniprot ID: APBP2_MOUSE
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity
Post Translational Modifications Rapidly degraded by the proteasome upon overexpression of a C-terminal fragment of APP.
Function Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(APPBP2) complex specifically recognizes proteins with a -Arg-Xaa-Xaa-Gly degron at the C-terminus, leading to their ubiquitination and degradation. The CRL2(APPBP2) complex mediates ubiquitination and degradation of truncated SELENOV selenoproteins produced by failed UGA/Sec decoding, which end with a -Arg-Xaa-Xaa-Gly degron. May play a role in intracellular protein transport: may be involved in the translocation of APP along microtubules toward the cell surface.
Protein Name Amyloid Protein-Binding Protein 2
Amyloid Beta Precursor Protein-Binding Protein 2
App-Bp2
Database Links
Cellular Localisation Nucleus
Cytoplasm
Cytoskeleton
Membrane
Peripheral Membrane Protein
Associated With Membranes And Microtubules
Alternative ELISA Names Amyloid Protein-Binding Protein 2 ELISA kit
Amyloid Beta Precursor Protein-Binding Protein 2 ELISA kit
App-Bp2 ELISA kit
Appbp2 ELISA kit
Kiaa0228 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance