• Human XRCC6 (X-Ray Repair Cross Complementing 6) Sandwich ELISA Kit Ready-To-Use (STJE0019522)

Human XRCC6 (X-Ray Repair Cross Complementing 6) Sandwich ELISA Kit Ready-To-Use (STJE0019522)

SKU:
STJE0019522

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.112ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This XRCC6 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: XRCC6
Gene ID: 2547
Uniprot ID: XRCC6_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity
Post Translational Modifications Phosphorylation by PRKDC may enhance helicase activity. Phosphorylation of Ser-51 does not affect DNA repair. ADP-ribosylated by PARP3.
Function Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a role in chromosome translocation. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection. Binding to DNA may be mediated by XRCC6. The XRCC5-XRRC6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription. In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.
Protein Name X-Ray Repair Cross-Complementing Protein 6
5'-Deoxyribose-5-Phosphate Lyase Ku70
5'-Drp Lyase Ku70
70 Kda Subunit Of Ku Antigen
Atp-Dependent Dna Helicase 2 Subunit 1
Atp-Dependent Dna Helicase Ii 70 Kda Subunit
Ctc Box-Binding Factor 75 Kda Subunit
Ctc75
Ctcbf
Dna Repair Protein Xrcc6
Lupus Ku Autoantigen Protein P70
Ku70
Thyroid-Lupus Autoantigen
Tlaa
X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 6
Database Links Reactome: R-HSA-164843
Reactome: R-HSA-1834949
Reactome: R-HSA-3270619
Reactome: R-HSA-5693571
Reactome: R-HSA-6798695
Cellular Localisation Nucleus
Chromosome
Alternative ELISA Names X-Ray Repair Cross-Complementing Protein 6 ELISA kit
5'-Deoxyribose-5-Phosphate Lyase Ku70 ELISA kit
5'-Drp Lyase Ku70 ELISA kit
70 Kda Subunit Of Ku Antigen ELISA kit
Atp-Dependent Dna Helicase 2 Subunit 1 ELISA kit
Atp-Dependent Dna Helicase Ii 70 Kda Subunit ELISA kit
Ctc Box-Binding Factor 75 Kda Subunit ELISA kit
Ctc75 ELISA kit
Ctcbf ELISA kit
Dna Repair Protein Xrcc6 ELISA kit
Lupus Ku Autoantigen Protein P70 ELISA kit
Ku70 ELISA kit
Thyroid-Lupus Autoantigen ELISA kit
Tlaa ELISA kit
X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 6 ELISA kit
XRCC6 ELISA kit
G22P1 ELISA kit
output

Information sourced from Uniprot.org

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