• Human WWP2 (WW Domain Containing E3 Ubiquitin Protein Ligase 2) Sandwich ELISA Kit Ready-To-Use (STJE0019505)

Human WWP2 (WW Domain Containing E3 Ubiquitin Protein Ligase 2) Sandwich ELISA Kit Ready-To-Use (STJE0019505)

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STJE0019505

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.27ng/mL
Detection Limit: 0.781-50ng/mL
Short Description: This WWP2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: WWP2
Gene ID: 11060
Uniprot ID: WWP2_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Detected in heart, throughout the brain, placenta, lung, liver, muscle, kidney and pancreas. Also detected in spleen and peripheral blood leukocytes.
Post Translational Modifications Autoubiquitinated. Ubiquitinated by the SCF(FBXL15) complex, leading to its degradation by the proteasome.
Function E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation.in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation.in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2.the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.
Protein Name Nedd4-Like E3 Ubiquitin-Protein Ligase Wwp2
Atrophin-1-Interacting Protein 2
Aip2
Hect-Type E3 Ubiquitin Transferase Wwp2
Ww Domain-Containing Protein 2
Database Links Reactome: R-HSA-8948751
Reactome: R-HSA-9013406
Reactome: R-HSA-9013409
Reactome: R-HSA-9013420
Reactome: R-HSA-9013507
Cellular Localisation Nucleus
Alternative ELISA Names Nedd4-Like E3 Ubiquitin-Protein Ligase Wwp2 ELISA kit
Atrophin-1-Interacting Protein 2 ELISA kit
Aip2 ELISA kit
Hect-Type E3 Ubiquitin Transferase Wwp2 ELISA kit
Ww Domain-Containing Protein 2 ELISA kit
WWP2 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance