• Human VRK1 (Vaccinia Related Kinase 1) Sandwich ELISA Kit (STJE0013063)

Human VRK1 (Vaccinia Related Kinase 1) Sandwich ELISA Kit (STJE0013063)

SKU:
STJE0013063

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.062ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This VRK1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: VRK1
Gene ID: 7443
Uniprot ID: VRK1_HUMAN
Sample Type: serum, plasma or other biological fluids.
Tissue Specificity Widely expressed. Highly expressed in fetal liver, testis and thymus.
Post Translational Modifications Autophosphorylated at various serine and threonine residues. Autophosphorylation does not impair its ability to phosphorylate p53/TP53. Phosphorylation by PLK3 leads to induction of Golgi fragmentation during mitosis.
Function Serine/threonine kinase involved in cell cycle, nuclear condensation and transcription regulation. Involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates KAT5 in response to DNA damage, promoting KAT5 association with chromatin and histone acetyltransferase activity. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.
Protein Name Serine/Threonine-Protein Kinase Vrk1
Vaccinia-Related Kinase 1
Database Links Reactome: R-HSA-2980766
Reactome: R-HSA-2995383
Cellular Localisation Nucleus
Cytoplasm
Dispersed Throughout The Cell But Not Located On Mitotic Spindle Or Chromatids During Mitosis
Alternative ELISA Names Serine/Threonine-Protein Kinase Vrk1 ELISA kit
Vaccinia-Related Kinase 1 ELISA kit
VRK1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance