• Human vHL (Von Hippel Lindau Tumor Suppressor) Sandwich ELISA Kit (STJE0013036)

Human vHL (Von Hippel Lindau Tumor Suppressor) Sandwich ELISA Kit (STJE0013036)

SKU:
STJE0013036

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.062ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This vHL Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: VHL
Gene ID: 7428
Uniprot ID: VHL_HUMAN
Sample Type: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Tissue Specificity Expressed in the adult and fetal brain and kidney.
Post Translational Modifications
Function Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2. Acts as a negative regulator of mTORC1 by promoting ubiquitination and degradation of RPTOR.
Protein Name Von Hippel-Lindau Disease Tumor Suppressor
Protein G7
Pvhl
Database Links Reactome: R-HSA-1234176
Reactome: R-HSA-3232142
Reactome: R-HSA-8951664
Reactome: R-HSA-9682706
Reactome: R-HSA-9694686
Reactome: R-HSA-9706019
Reactome: R-HSA-983168
Cellular Localisation Isoform 1: Cytoplasm
Cell Membrane
Peripheral Membrane Protein
Endoplasmic Reticulum
Nucleus
Found Predominantly In The Cytoplasm And With Less Amounts Nuclear Or Membrane-Associated
Colocalizes With Adrb2 At The Cell Membrane
Isoform 3: Cytoplasm
Equally Distributed Between The Nucleus And The Cytoplasm But Not Membrane-Associated
Alternative ELISA Names Von Hippel-Lindau Disease Tumor Suppressor ELISA kit
Protein G7 ELISA kit
Pvhl ELISA kit
VHL ELISA kit
output

Information sourced from Uniprot.org

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