• Human VDAC1 (Voltage Dependent Anion Channel Protein 1) Sandwich ELISA Kit Ready-To-Use (STJE0019380)

Human VDAC1 (Voltage Dependent Anion Channel Protein 1) Sandwich ELISA Kit Ready-To-Use (STJE0019380)

SKU:
STJE0019380

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 13.8pg/mL
Detection Limit: 31.2-2000pg/mL
Short Description: This VDAC1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: VDAC1
Gene ID: 7416
Uniprot ID: VDAC1_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Expressed in erythrocytes (at protein level). Expressed in heart, liver and skeletal muscle.
Post Translational Modifications Phosphorylation at Ser-193 by NEK1 promotes the open conformational state preventing excessive mitochondrial membrane permeability and subsequent apoptotic cell death after injury. Phosphorylation by the AKT-GSK3B axis stabilizes the protein probably by preventing ubiquitin-mediated proteasomal degradation. Ubiquitinated. Undergoes monoubiquitination and polyubiquitination by PRKN.monoubiquitination at Lys-274 inhibits apoptosis, whereas polyubiquitination leads to its degradation and promotes mitophagy. Deubiquitinated by USP30.
Function Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules.in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol. In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis.polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. May mediate ATP export from cells.
Protein Name Voltage-Dependent Anion-Selective Channel Protein 1
Vdac-1
Hvdac1
Outer Mitochondrial Membrane Protein Porin 1
Plasmalemmal Porin
Porin 31hl
Porin 31hm
Database Links Reactome: R-HSA-1268020
Reactome: R-HSA-5205685
Reactome: R-HSA-5689880
Reactome: R-HSA-70268
Reactome: R-HSA-8949215
Cellular Localisation Mitochondrion Outer Membrane
Multi-Pass Membrane Protein
Cell Membrane
Membrane Raft
Alternative ELISA Names Voltage-Dependent Anion-Selective Channel Protein 1 ELISA kit
Vdac-1 ELISA kit
Hvdac1 ELISA kit
Outer Mitochondrial Membrane Protein Porin 1 ELISA kit
Plasmalemmal Porin ELISA kit
Porin 31hl ELISA kit
Porin 31hm ELISA kit
VDAC1 ELISA kit
VDAC ELISA kit
output

Information sourced from Uniprot.org

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