Applications: | ELISA |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Sensitivity: | 0.108ng/mL |
Detection Limit: | 0.312-20ng/mL |
Short Description: | This USP14 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
Storage Instruction: | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
Assay Time: | 3 hrs |
Gene Symbol: | USP14 |
Gene ID: | 9097 |
Uniprot ID: | UBP14_HUMAN |
Immunogen Region: | Ready-To-Use |
Sample Type: | tissue homogenates or other biological fluids. |
Tissue Specificity | |
Post Translational Modifications | |
Function | Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs). Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation. |
Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 14 Deubiquitinating Enzyme 14 Ubiquitin Thioesterase 14 Ubiquitin-Specific-Processing Protease 14 |
Database Links | Reactome: R-HSA-5689880 Reactome: R-HSA-9758274 |
Cellular Localisation | Cytoplasm Cell Membrane Peripheral Membrane Protein |
Alternative ELISA Names | Ubiquitin Carboxyl-Terminal Hydrolase 14 ELISA kit Deubiquitinating Enzyme 14 ELISA kit Ubiquitin Thioesterase 14 ELISA kit Ubiquitin-Specific-Processing Protease 14 ELISA kit USP14 ELISA kit TGT ELISA kit |
output |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance