| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.127ng/mL |
| Detection Limit: |
0.312-20ng/mL |
| Short Description: |
This URAT1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Tissue Specificity | Detected in kidney (at protein level). Detected in fetal and adult kidney. Detected in epithelial cells of proximal tubules in renal cortex. |
| Post Translational Modifications | N-glycosylated. |
| Function | Electroneutral antiporter that translocates urate across the apical membrane of proximal tubular cells in exchange for monovalent organic or inorganic anions. Involved in renal reabsorption of urate and helps maintaining blood levels of uric acid. Mediates urate uptake by an exchange with organic anions such as (S)-lactate and nicotinate, and inorganic anion Cl(-). Other inorganic anions such as Br(-), I(-) and NO3(-) may also act as counteranions that exchange for urate. Also mediates orotate tubular uptake coupled with nicotinate efflux and to a lesser extent with lactate efflux, therefore displaying a potential role in orotate renal reabsorption. Orotate transport is Cl(-)-dependent. |
| Protein Name | Solute Carrier Family 22 Member 12Organic Anion Transporter 4-Like ProteinRenal-Specific TransporterRstUrate Anion Exchanger 1Urat1Urate -Anion Antiporter Slc22a12 |
| Database Links | Reactome: R-HSA-561048Reactome: R-HSA-5619071 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane Protein |
| Alternative ELISA Names | Solute Carrier Family 22 Member 12 ELISA kitOrganic Anion Transporter 4-Like Protein ELISA kitRenal-Specific Transporter ELISA kitRst ELISA kitUrate Anion Exchanger 1 ELISA kitUrat1 ELISA kitUrate -Anion Antiporter Slc22a12 ELISA kitSLC22A12 ELISA kitOATL4 ELISA kitURAT1 ELISA kitUNQ6453 ELISA kitPRO34004 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
