• Human URAT1 (Urate Transporter 1) Sandwich ELISA Kit Ready-To-Use (STJE0019336)

Human URAT1 (Urate Transporter 1) Sandwich ELISA Kit Ready-To-Use (STJE0019336)

SKU:
STJE0019336

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.127ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This URAT1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: SLC22A12
Gene ID: 116085
Uniprot ID: S22AC_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Detected in kidney (at protein level). Detected in fetal and adult kidney. Detected in epithelial cells of proximal tubules in renal cortex.
Post Translational Modifications N-glycosylated.
Function Electroneutral antiporter that translocates urate across the apical membrane of proximal tubular cells in exchange for monovalent organic or inorganic anions. Involved in renal reabsorption of urate and helps maintaining blood levels of uric acid. Mediates urate uptake by an exchange with organic anions such as (S)-lactate and nicotinate, and inorganic anion Cl(-). Other inorganic anions such as Br(-), I(-) and NO3(-) may also act as counteranions that exchange for urate. Also mediates orotate tubular uptake coupled with nicotinate efflux and to a lesser extent with lactate efflux, therefore displaying a potential role in orotate renal reabsorption. Orotate transport is Cl(-)-dependent.
Protein Name Solute Carrier Family 22 Member 12
Organic Anion Transporter 4-Like Protein
Renal-Specific Transporter
Rst
Urate Anion Exchanger 1
Urat1
Urate -Anion Antiporter Slc22a12
Database Links Reactome: R-HSA-561048
Reactome: R-HSA-5619071
Cellular Localisation Apical Cell Membrane
Multi-Pass Membrane Protein
Alternative ELISA Names Solute Carrier Family 22 Member 12 ELISA kit
Organic Anion Transporter 4-Like Protein ELISA kit
Renal-Specific Transporter ELISA kit
Rst ELISA kit
Urate Anion Exchanger 1 ELISA kit
Urat1 ELISA kit
Urate -Anion Antiporter Slc22a12 ELISA kit
SLC22A12 ELISA kit
OATL4 ELISA kit
URAT1 ELISA kit
UNQ6453 ELISA kit
PRO34004 ELISA kit
output

Information sourced from Uniprot.org

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