| Host: |
sf9 Insect cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human Ubiquitin carboxyl-terminal hydrolase 35/USP35-GST Tag protein was developed from sf9 insect cells and has a target region of GST Tag. For use in research applications. |
| Formulation: |
20 mM Tris, 150 mM NaCl, 2 mM BetaME, 10% Glycerol |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Post Translational Modifications | Ubiquitinated by CHIP/STUB1 in an HSP90-dependent manner.leading to proteasomal degradation. This ubiquitination can be reversed through auto-deubiquitinating activity. |
| Function | Deubiquitinase that plays a role in different processes including cell cycle regulation, mitophagy or endoplasmic reticulum stress. Inhibits TNFalpha-induced NF-kappa-B activation through stabilizing TNIP2 protein via deubiquitination. Plays an essential role during mitosis by deubiquitinating and thereby regulating the levels of Aurora B/AURKB protein. In addition, regulates the protein levels of other key component of the chromosomal passenger complex (CPC) such as survivin/BIRC5 or Borealin/CDCA8 by enhancing their stability. Regulates the degradation of mitochondria through the process of autophagy termed mitophagy. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 35Deubiquitinating Enzyme 35Ubiquitin Thioesterase 35Ubiquitin-Specific-Processing Protease 35 |
| Cellular Localisation | CytoplasmMitochondrionOnly Associates With Polarized MitochondriaAnd Rapidly Translocates To The Cytosol During Mitophagy |
| Alternative Protein Names | Ubiquitin Carboxyl-Terminal Hydrolase 35 proteinDeubiquitinating Enzyme 35 proteinUbiquitin Thioesterase 35 proteinUbiquitin-Specific-Processing Protease 35 proteinUSP35 proteinKIAA1372 proteinUSP34 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
