• Human tTBK2 (Tau-Tubulin Kinase 2) Sandwich ELISA Kit (STJE0012850)

Human tTBK2 (Tau-Tubulin Kinase 2) Sandwich ELISA Kit (STJE0012850)

SKU:
STJE0012850

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.124ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This tTBK2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: TTBK2
Gene ID: 146057
Uniprot ID: TTBK2_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity
Post Translational Modifications
Function Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro. Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis.
Protein Name Tau-Tubulin Kinase 2
Database Links Reactome: R-HSA-5620912
Cellular Localisation Cell Projection
Cilium
Cytoplasm
Cytoskeleton
Cilium Basal Body
Microtubule Organizing Center
Centrosome
Centriole
Cytosol
Nucleus
Localizes To The Transition Zone In Primary Cilia In Response To Cell Cycle Signals That Promote Ciliogenesis
May Also Be Present In Cytosol And
At Lower Level In The Nucleus
Alternative ELISA Names Tau-Tubulin Kinase 2 ELISA kit
TTBK2 ELISA kit
KIAA0847 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance