Human TSHR/LGR3 protein (Recombinant) (C-Fc) (STJP009509)

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STJP009509
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human TSHR/LGR3-C-Fc protein was developed from mammalian cells and has a target region of C-Fc. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: TSHR
Gene ID: 7253
Uniprot ID: TSHR_HUMAN
Immunogen Region: Met22-Gln289
Immunogen: Homo sapiens (Human)
Post Translational Modifications Glycosylated. Sulfated. Sulfation on Tyr-385 plays a role in thyrotropin receptor binding and activation.
Function Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.
Protein Name Thyrotropin Receptor
Thyroid-Stimulating Hormone Receptor
Tsh-R
Database Links Reactome: R-HSA-375281
Reactome: R-HSA-418555
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Basolateral Cell Membrane
Alternative Protein Names Thyrotropin Receptor protein
Thyroid-Stimulating Hormone Receptor protein
Tsh-R protein
TSHR protein
LGR3 protein

Information sourced from Uniprot.org

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