• Human TIRAP (Toll Interleukin 1 Receptor Domain Containing Adaptor Protein) Sandwich ELISA Kit (STJE0012613)

Human TIRAP (Toll Interleukin 1 Receptor Domain Containing Adaptor Protein) Sandwich ELISA Kit (STJE0012613)

SKU:
STJE0012613

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.109ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This TIRAP Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: TIRAP
Gene ID: 114609
Uniprot ID: TIRAP_HUMAN
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain.
Post Translational Modifications Phosphorylated by IRAK1 and IRAK4. Also phosphorylated by BTK. Polyubiquitinated. Polyubiquitination follows phosphorylation by BTK and leads to TIRAP degradation.
Function Adapter involved in TLR2, TLR4 and RAGE signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha (TNF) and interleukin-6 (IL6).
Protein Name Toll/Interleukin-1 Receptor Domain-Containing Adapter Protein
Tir Domain-Containing Adapter Protein
Adaptor Protein Wyatt
Myd88 Adapter-Like Protein
Myd88-2
Database Links Reactome: R-HSA-1236974
Reactome: R-HSA-166058
Reactome: R-HSA-5602498
Reactome: R-HSA-5603041
Cellular Localisation Cytoplasm
Cell Membrane
Membrane
Colocalizes With Dab2ip At The Plasma Membrane
Alternative ELISA Names Toll/Interleukin-1 Receptor Domain-Containing Adapter Protein ELISA kit
Tir Domain-Containing Adapter Protein ELISA kit
Adaptor Protein Wyatt ELISA kit
Myd88 Adapter-Like Protein ELISA kit
Myd88-2 ELISA kit
TIRAP ELISA kit
MAL ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance