Human TBX6 protein (Recombinant) (N-His) (STJP010807)

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STJP010807
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human TBX6-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: TBX6
Gene ID: 6911
Uniprot ID: TBX6_HUMAN
Immunogen Region: Gly90-Lys289
Immunogen: Homo sapiens (Human)
Function T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia.
Protein Name T-Box Transcription Factor Tbx6
T-Box Protein 6
Database Links Reactome: R-HSA-9793380
Reactome: R-HSA-9824272
Reactome: R-HSA-9832991
Cellular Localisation Nucleus
Alternative Protein Names T-Box Transcription Factor Tbx6 protein
T-Box Protein 6 protein
TBX6 protein

Information sourced from Uniprot.org

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