• Human STX1A (Syntaxin 1A, Brain) Sandwich ELISA Kit Ready-To-Use (STJE0018775)

Human STX1A (Syntaxin 1A, Brain) Sandwich ELISA Kit Ready-To-Use (STJE0018775)

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STJE0018775

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.056ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This STX1A Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: STX1A
Gene ID: 6804
Uniprot ID: STX1A_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Isoform 1: Highly expressed in embryonic spinal cord and ganglia and in adult cerebellum and cerebral cortex. Isoform 2: Expressed in heart, liver, fat, skeletal muscle, kidney and brain.
Post Translational Modifications Phosphorylated by CK2. Phosphorylation at Ser-188 by DAPK1 significantly decreases its interaction with STXBP1. Sumoylated, sumoylation is required for regulation of synaptic vesicle endocytosis.
Function Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion. Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm. Also plays an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1).
Protein Name Syntaxin-1a
Neuron-Specific Antigen Hpc-1
Database Links Reactome: R-HSA-181429
Reactome: R-HSA-181430
Reactome: R-HSA-210500
Reactome: R-HSA-212676
Reactome: R-HSA-264642
Reactome: R-HSA-264876
Reactome: R-HSA-422356
Reactome: R-HSA-449836
Reactome: R-HSA-5250971
Reactome: R-HSA-5682910
Reactome: R-HSA-6794361
Reactome: R-HSA-888590
Reactome: R-HSA-9609523
Reactome: R-HSA-9662360
Cellular Localisation Cytoplasmic Vesicle
Secretory Vesicle
Synaptic Vesicle Membrane
Single-Pass Type Iv Membrane Protein
Synapse
Synaptosome
Cell Membrane
Colocalizes With Kcnb1 At The Cell Membrane
Isoform 2: Secreted
Alternative ELISA Names Syntaxin-1a ELISA kit
Neuron-Specific Antigen Hpc-1 ELISA kit
STX1A ELISA kit
STX1 ELISA kit
output

Information sourced from Uniprot.org

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