| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.114ng/mL |
| Detection Limit: |
0.312-20ng/mL |
| Short Description: |
This SLC39A6 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
SLC39A6 |
| Gene ID: |
25800 |
| Uniprot ID: |
S39A6_HUMAN |
| Sample Type: |
tissue homogenates or other biological fluids. |
| Tissue Specificity | Highly expressed in the breast, prostate, placenta, kidney, pituitary and corpus callosum. Weakly expressed in heart and intestine. Also highly expressed in cells derived from an adenocarcinoma of the cervix and lung carcinoma. |
| Post Translational Modifications | Cleaved on the N-terminus before locating to the plasma membrane. N-glycosylated. Phosphorylated by ZAP70 in response to TCR stimulation leading to its activation. |
| Function | Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT). When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to-mesenchymal transition (EMT). The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT. Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 in the nucleus to down-regulate adherence genes such as CDH1, causing loss of cell adherence. In addition, the SLC39A10-SLC39A6 heterodimer plays an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis. Participates in the T-cell receptor signaling regulation by mediating cellular zinc uptake into activated lymphocytes. Regulates the zinc influx necessary for proper meiotic progression to metaphase II (MII) that allows the oocyte-to-egg transition. |
| Protein Name | Zinc Transporter Zip6Estrogen-Regulated Protein Liv-1Solute Carrier Family 39 Member 6Zrt- And Irt-Like Protein 6Zip-6 |
| Database Links | Reactome: R-HSA-442380 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionLamellipodium MembraneMembrane RaftApical Cell MembraneLocalizes To Lipid Rafts In T Cells And Is Recruited Into The Immunological Synapse In Response To Tcr StimulationIn The Choroid Plexus Is Limited To The Apical Membrane In Epithelial Cells |
| Alternative ELISA Names | Zinc Transporter Zip6 ELISA kitEstrogen-Regulated Protein Liv-1 ELISA kitSolute Carrier Family 39 Member 6 ELISA kitZrt- And Irt-Like Protein 6 ELISA kitZip-6 ELISA kitSLC39A6 ELISA kitLIV1 ELISA kitZIP6 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
