Human SIRT4 protein (Recombinant) (N-His) (STJP006293)

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STJP006293
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SIRT4-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SIRT4
Gene ID: 23409
Uniprot ID: SIR4_HUMAN
Immunogen Region: Ser28-Cys314
Immunogen: Homo sapiens (Human)
Function Acts as a NAD-dependent protein lipoamidase, biotinylase, deacetylase and ADP-ribosyl transferase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Does not seem to deacetylate PC. Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1-PPARA interaction probably through the regulation of NAD(+) levels. Down-regulates insulin secretion.
Protein Name Nad-Dependent Protein Lipoamidase Sirtuin-4 - Mitochondrial
Nad-Dependent Adp-Ribosyltransferase Sirtuin-4
Nad-Dependent Protein Biotinylase Sirtuin-4
Nad-Dependent Protein Deacetylase Sirtuin-4
Regulatory Protein Sir2 Homolog 4
Sir2-Like Protein 4
Database Links Reactome: R-HSA-204174
Reactome: R-HSA-2151201
Cellular Localisation Mitochondrion Matrix
Alternative Protein Names Nad-Dependent Protein Lipoamidase Sirtuin-4 - Mitochondrial protein
Nad-Dependent Adp-Ribosyltransferase Sirtuin-4 protein
Nad-Dependent Protein Biotinylase Sirtuin-4 protein
Nad-Dependent Protein Deacetylase Sirtuin-4 protein
Regulatory Protein Sir2 Homolog 4 protein
Sir2-Like Protein 4 protein
SIRT4 protein
SIR2L4 protein

Information sourced from Uniprot.org

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