| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.056ng/mL |
| Detection Limit: |
0.156-10ng/mL |
| Short Description: |
This SGLT1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
SLC5A1 |
| Gene ID: |
6523 |
| Uniprot ID: |
SC5A1_HUMAN |
| Sample Type: |
tissue homogenates or other biological fluids. |
| Tissue Specificity | Expressed in intestine. Expressed in endometrial cells. |
| Post Translational Modifications | N-glycosylation is not necessary for the cotransporter function. |
| Function | Electrogenic Na(+)-coupled sugar simporter that actively transports D-glucose or D-galactose at the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump. Has a primary role in the transport of dietary monosaccharides from enterocytes to blood. Responsible for the absorption of D-glucose or D-galactose across the apical brush-border membrane of enterocytes, whereas basolateral exit is provided by GLUT2. Additionally, functions as a D-glucose sensor in enteroendocrine cells, triggering the secretion of the incretins GCG and GIP that control food intake and energy homeostasis. Together with SGLT2, functions in reabsorption of D-glucose from glomerular filtrate, playing a nonredundant role in the S3 segment of the proximal tubules. Transports D-glucose into endometrial epithelial cells, controlling glycogen synthesis and nutritional support for the embryo as well as the decidual transformation of endometrium prior to conception. Acts as a water channel enabling passive water transport across the plasma membrane in response to the osmotic gradient created upon sugar and Na(+) uptake. Has high water conductivity, comparable to aquaporins, and therefore is expected to play an important role in transepithelial water permeability, especially in the small intestine. |
| Protein Name | Sodium/Glucose Cotransporter 1Na(+/Glucose Cotransporter 1High Affinity Sodium-Glucose CotransporterSolute Carrier Family 5 Member 1 |
| Database Links | Reactome: R-HSA-189200Reactome: R-HSA-5656364Reactome: R-HSA-8981373 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane Protein |
| Alternative ELISA Names | Sodium/Glucose Cotransporter 1 ELISA kitNa(+/Glucose Cotransporter 1 ELISA kitHigh Affinity Sodium-Glucose Cotransporter ELISA kitSolute Carrier Family 5 Member 1 ELISA kitSLC5A1 ELISA kitNAGT ELISA kitSGLT1 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
