• Human RYR2 (Ryanodine Receptor 2, Cardiac) Sandwich ELISA Kit (STJE0011963)

Human RYR2 (Ryanodine Receptor 2, Cardiac) Sandwich ELISA Kit (STJE0011963)

SKU:
STJE0011963

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.107ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This RYR2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: RYR2
Gene ID: 6262
Uniprot ID: RYR2_HUMAN
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Detected in heart muscle (at protein level). Heart muscle, brain (cerebellum and hippocampus) and placenta.
Post Translational Modifications Channel activity is modulated by phosphorylation. Phosphorylation at Ser-2808 and Ser-2814 increases the open probability of the calcium channel. Phosphorylation is increased in failing heart, leading to calcium leaks and increased cytoplasmic Ca(2+) levels. Phosphorylation at Ser-2031 by PKA enhances the response to lumenal calcium.
Function Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) cytosolic levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.
Protein Name Ryanodine Receptor 2
Ryr-2
Ryr2
Hryr-2
Cardiac Muscle Ryanodine Receptor
Cardiac Muscle Ryanodine Receptor-Calcium Release Channel
Type 2 Ryanodine Receptor
Database Links Reactome: R-HSA-2672351
Reactome: R-HSA-5578775
Cellular Localisation Sarcoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
Alternative ELISA Names Ryanodine Receptor 2 ELISA kit
Ryr-2 ELISA kit
Ryr2 ELISA kit
Hryr-2 ELISA kit
Cardiac Muscle Ryanodine Receptor ELISA kit
Cardiac Muscle Ryanodine Receptor-Calcium Release Channel ELISA kit
Type 2 Ryanodine Receptor ELISA kit
RYR2 ELISA kit
output

Information sourced from Uniprot.org

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