• Human RNF43 protein (Recombinant) (C-hFC) (STJP002421)
  • Human RNF43 protein (Recombinant) (C-hFC) (STJP002421)
  • Human RNF43 protein (Recombinant) (C-hFC) (STJP002421)
  • Human RNF43 protein (Recombinant) (C-hFC) (STJP002421)
  • Human RNF43 protein (Recombinant) (C-hFC) (STJP002421)

Human RNF43 protein (Recombinant) (C-hFC) (STJP002421)

SKU:
STJP002421-100

£319.50
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Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human RNF43-C-hFC protein was developed from hek293 cells and has a target region of C-hFC. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity: 1.Immobilized Human R spondin 1, His Tag at 5 Mu g/mL (100 Mu L/well) on the plate. Dose response curve for Human RNF34, hFc Tag with the EC50 of 0.4 Mu g/mL determined by ELISA.2.Immobilized Human R-Spondin 3, His Tag at 1 Mu g/mL (100 Mu L/well) on
Gene Symbol: RNF43
Gene ID: 54894
Uniprot ID: RNF43_HUMAN
Immunogen Region: Gly24-Tyr197
Immunogen: Recombinant Human RNF43 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly24-Tyr197) of human RNF43 (Accession #NP_001292473.1) fused with a hFc tag at the C-terminus.
Post Translational Modifications Autoubiquitinated.
Function E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification.
Protein Name E3 Ubiquitin-Protein Ligase Rnf43
Ring Finger Protein 43
Ring-Type E3 Ubiquitin Transferase Rnf43
Database Links Reactome: R-HSA-4641263
Reactome: R-HSA-5340588
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Endoplasmic Reticulum Membrane
Nucleus Envelope
According To A Report
May Be Secreted
Alternative Protein Names E3 Ubiquitin-Protein Ligase Rnf43 protein
Ring Finger Protein 43 protein
Ring-Type E3 Ubiquitin Transferase Rnf43 protein
RNF43 protein

Information sourced from Uniprot.org

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