| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.126ng/mL |
| Detection Limit: |
0.312-20ng/mL |
| Short Description: |
This RNASEN Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
DROSHA |
| Gene ID: |
29102 |
| Uniprot ID: |
RNC_HUMAN |
| Sample Type: |
tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | |
| Function | Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. |
| Protein Name | Ribonuclease 3Protein DroshaRibonuclease IiiRnase IiiP241 |
| Database Links | Reactome: R-HSA-203927 |
| Cellular Localisation | NucleusNucleolusA Fraction Is Translocated To The Nucleolus During The S Phase Of The Cell CycleLocalized In Gw Bodies (Gwbs)Also Known As P-Bodies |
| Alternative ELISA Names | Ribonuclease 3 ELISA kitProtein Drosha ELISA kitRibonuclease Iii ELISA kitRnase Iii ELISA kitP241 ELISA kitDROSHA ELISA kitRN3 ELISA kitRNASE3L ELISA kitRNASEN ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
