• Human RHO (Rhodopsin) Sandwich ELISA Kit (STJE0011885)

Human RHO (Rhodopsin) Sandwich ELISA Kit (STJE0011885)

SKU:
STJE0011885

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.118ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This RHO Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: RHO
Gene ID: 6010
Uniprot ID: OPSD_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Rod shaped photoreceptor cells which mediate vision in dim light.
Post Translational Modifications Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region. After activation by light, phosphorylated by GRK1 (in vitro). Contains one covalently linked retinal chromophore. Upon light absorption, the covalently bound 11-cis-retinal is converted to all-trans-retinal. After hydrolysis of the Schiff base and release of the covalently bound all-trans-retinal, active rhodopsin is regenerated by binding of a fresh molecule of 11-cis-retinal.
Function Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of the chromophore 11-cis-retinal to all-trans-retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling.
Protein Name Rhodopsin
Opsin-2
Database Links Reactome: R-HSA-2453902
Reactome: R-HSA-2485179
Reactome: R-HSA-2514859
Reactome: R-HSA-418594
Reactome: R-HSA-419771
Reactome: R-HSA-5620916
Cellular Localisation Membrane
Multi-Pass Membrane Protein
Cell Projection
Cilium
Photoreceptor Outer Segment
Synthesized In The Inner Segment (Is) Of Rod Photoreceptor Cells Before Vectorial Transport To Disk Membranes In The Rod Outer Segment (Os) Photosensory Cilia
Alternative ELISA Names Rhodopsin ELISA kit
Opsin-2 ELISA kit
RHO ELISA kit
OPN2 ELISA kit
output

Information sourced from Uniprot.org

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