||FOR RESEARCH USE ONLY (RUO).
||Recombinant-Human R-Spondin1-protein was developed from hek293. For use in research applications.
||Recombinant Human R-spondin1 is lyophilized from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose.
||Recombinant R-spondin1 can be stored in working aliquots at 2-8°C for one month, or at-20°C to-70°C for twelve months. Avoid repeated freeze/thaw cycles.
||Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
| Tissue Specificity || Abundantly expressed in adrenal glands, ovary, testis, thyroid and trachea but not in bone marrow, spinal cord, stomach, leukocytes colon, small intestine, prostate, thymus and spleen. |
| Function || Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Regulates Wnt signaling by antagonizing DKK1/KREM1-mediated internalization of LRP6 through an interaction with KREM1. |
| Protein Name || R-Spondin-1Roof Plate-Specific Spondin-1Hrspo1 |
| Database Links || Reactome: R-HSA-4641263 |
| Cellular Localisation || SecretedNucleusSeems To Mainly Localize To Nucleoli |
| Alternative Antibody Names || Anti-R-Spondin-1 antibodyAnti-Roof Plate-Specific Spondin-1 antibodyAnti-Hrspo1 antibodyAnti-RSPO1 antibody |
Information sourced from Uniprot.org
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