| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.29ng/mL |
| Detection Limit: | 0.781-50ng/mL |
| Short Description: | This PTPN11 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 3 hrs |
| Gene Symbol: | PTPN11 |
| Gene ID: | 5781 |
| Uniprot ID: | PTN11_HUMAN |
| Immunogen Region: | Ready-To-Use |
| Sample Type: | tissue homogenates or other biological fluids. |
| Tissue Specificity | Widely expressed, with highest levels in heart, brain, and skeletal muscle. |
| Post Translational Modifications | Phosphorylated on Tyr-542 and Tyr-580 upon receptor protein tyrosine kinase activation.which creates a binding site for GRB2 and other SH2-containing proteins. Phosphorylated upon activation of the receptor-type kinase FLT3. Phosphorylated upon activation of the receptor-type kinase PDGFRA. Phosphorylated by activated PDGFRB. |
| Function | Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity. Dephosphorylates CDC73. Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification. Dephosphorylates tyrosine-phosphorylated NEDD9/CAS-L. |
| Protein Name | Tyrosine-Protein Phosphatase Non-Receptor Type 11Protein-Tyrosine Phosphatase 1dPtp-1dProtein-Tyrosine Phosphatase 2cPtp-2cSh-Ptp2Shp-2Shp2Sh-Ptp3 |
| Database Links | Reactome: R-HSA-1059683Reactome: R-HSA-109704Reactome: R-HSA-110056Reactome: R-HSA-112411Reactome: R-HSA-114604Reactome: R-HSA-1170546Reactome: R-HSA-1257604Reactome: R-HSA-1295596Reactome: R-HSA-1433557Reactome: R-HSA-180292Reactome: R-HSA-186763Reactome: R-HSA-210990Reactome: R-HSA-210993Reactome: R-HSA-2219530Reactome: R-HSA-2586552Reactome: R-HSA-388841Reactome: R-HSA-389513Reactome: R-HSA-389948Reactome: R-HSA-391160Reactome: R-HSA-418886Reactome: R-HSA-432142Reactome: R-HSA-512988Reactome: R-HSA-5654689Reactome: R-HSA-5654693Reactome: R-HSA-5654695Reactome: R-HSA-5654700Reactome: R-HSA-5654706Reactome: R-HSA-5654710Reactome: R-HSA-5654712Reactome: R-HSA-5654720Reactome: R-HSA-5654726Reactome: R-HSA-5654727Reactome: R-HSA-5654732Reactome: R-HSA-5654733Reactome: R-HSA-6811558Reactome: R-HSA-877312Reactome: R-HSA-8853659Reactome: R-HSA-8854691Reactome: R-HSA-8865999Reactome: R-HSA-8934593Reactome: R-HSA-9008059Reactome: R-HSA-9028731Reactome: R-HSA-909733Reactome: R-HSA-912694Reactome: R-HSA-936964Reactome: R-HSA-9607240Reactome: R-HSA-9645135Reactome: R-HSA-9674555Reactome: R-HSA-9680350Reactome: R-HSA-9702518Reactome: R-HSA-9703648Reactome: R-HSA-9705671 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative ELISA Names | Tyrosine-Protein Phosphatase Non-Receptor Type 11 ELISA kitProtein-Tyrosine Phosphatase 1d ELISA kitPtp-1d ELISA kitProtein-Tyrosine Phosphatase 2c ELISA kitPtp-2c ELISA kitSh-Ptp2 ELISA kitShp-2 ELISA kitShp2 ELISA kitSh-Ptp3 ELISA kitPTPN11 ELISA kitPTP2C ELISA kitSHPTP2 ELISA kit |
| output |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
