| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.108ng/mL |
| Detection Limit: |
0.312-20ng/mL |
| Short Description: |
This PRDX6 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
PRDX6 |
| Gene ID: |
9588 |
| Uniprot ID: |
PRDX6_HUMAN |
| Sample Type: |
serum, plasma, tissue homogenates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | Irreversibly inactivated by overoxidation of Cys-47 to sulfinic acid (Cys-SO(2)H) and sulfonic acid (Cys-SO(3)H) forms upon oxidative stress. Phosphorylation at Thr-177 by MAP kinases increases the phospholipase activity of the enzyme. The phosphorylated form exhibits a greater lysophosphatidylcholine acyltransferase activity compared to the non-phosphorylated form. |
| Function | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis. Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC). Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate. |
| Protein Name | Peroxiredoxin-61-Cys Peroxiredoxin1-Cys Prx24 Kda ProteinAcidic Calcium-Independent Phospholipase A2Aipla2Antioxidant Protein 2Glutathione-Dependent PeroxiredoxinLiver 2d Page Spot 40Lysophosphatidylcholine Acyltransferase 5Lpc Acyltransferase 5Lpcat-5Lyso-Pc Acyltransferase 5Non-Selenium Glutathione PeroxidaseNsgpxRed Blood Cells Page Spot 12 |
| Database Links | Reactome: R-HSA-3299685Reactome: R-HSA-6798695 |
| Cellular Localisation | CytoplasmLysosomeAlso Found In Lung Secretory Organelles (Lamellar Bodies) |
| Alternative ELISA Names | Peroxiredoxin-6 ELISA kit1-Cys Peroxiredoxin ELISA kit1-Cys Prx ELISA kit24 Kda Protein ELISA kitAcidic Calcium-Independent Phospholipase A2 ELISA kitAipla2 ELISA kitAntioxidant Protein 2 ELISA kitGlutathione-Dependent Peroxiredoxin ELISA kitLiver 2d Page Spot 40 ELISA kitLysophosphatidylcholine Acyltransferase 5 ELISA kitLpc Acyltransferase 5 ELISA kitLpcat-5 ELISA kitLyso-Pc Acyltransferase 5 ELISA kitNon-Selenium Glutathione Peroxidase ELISA kitNsgpx ELISA kitRed Blood Cells Page Spot 12 ELISA kitPRDX6 ELISA kitAOP2 ELISA kitKIAA0106 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
