Human PPIase A/PPIA protein (Recombinant) (No tag) (STJP000790)

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Host:	E. coli
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human PPIase A/PPIA-No tag protein was developed from e. coli and has a target region of No tag. For use in research applications.

Formulation:

Lyophilized from a 0.22 Mu m filtered solution of 50mM TRIS, 150mM NaCl, pH 8.0. Contact us for customized product form or formulation.

Gene Symbol:	PPIA
Gene ID:	5478
Uniprot ID:	PPIA_HUMAN
Immunogen:	Recombinant Human PPIase A/PPIA Protein is produced by E. coli expression system. The target protein is expressed with sequence (Met1-Glu165) of human PPIA (Accession #NP_066953.1).

Post Translational Modifications	Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization and stabilizes cis rather than trans forms of the HIV-1 capsid. PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition. Acetylation at Lys-125 favors its interaction with TARDBP.
Function	Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation. Activates endothelial cells (ECs) in a pro-inflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1. Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis. In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2. Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1. Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates. Plays an important role in platelet activation and aggregation. Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton. Binds heparan sulfate glycosaminoglycans. Inhibits replication of influenza A virus (IAV). Inhibits ITCH/AIP4-mediated ubiquitination of matrix protein 1 (M1) of IAV by impairing the interaction of ITCH/AIP4 with M1, followed by the suppression of the nuclear export of M1, and finally reduction of the replication of IAV. (Microbial infection) May act as a mediator between human SARS coronavirus nucleoprotein and BSG/CD147 in the process of invasion of host cells by the virus. (Microbial infection) Stimulates RNA-binding ability of HCV NS5A in a peptidyl-prolyl cis-trans isomerase activity-dependent manner.
Protein Name	Peptidyl-Prolyl Cis-Trans Isomerase A Ppiase A Cyclophilin A Cyclosporin A-Binding Protein Rotamase A Cleaved Into - Peptidyl-Prolyl Cis-Trans Isomerase A - N-Terminally Processed
Database Links	Reactome: R-HSA-114608 Reactome: R-HSA-162585 Reactome: R-HSA-162588 Reactome: R-HSA-162592 Reactome: R-HSA-162594 Reactome: R-HSA-164516 Reactome: R-HSA-164525 Reactome: R-HSA-173107 Reactome: R-HSA-175474 Reactome: R-HSA-180689 Reactome: R-HSA-2025928 Reactome: R-HSA-210991 Reactome: R-HSA-6798695 Reactome: R-HSA-8950505 Reactome: R-HSA-9692916
Cellular Localisation	Cytoplasm Secreted Nucleus Secretion Occurs In Response To Oxidative Stress In Vascular Smooth Muscle Through A Vesicular Secretory Pathway That Includes Rho Gtpase Signaling Actin Remodeling And Myosin Ii Activation
Alternative Protein Names	Peptidyl-Prolyl Cis-Trans Isomerase A protein Ppiase A protein Cyclophilin A protein Cyclosporin A-Binding Protein protein Rotamase A Cleaved Into - Peptidyl-Prolyl Cis-Trans Isomerase A - N-Terminally Processed protein PPIA protein CYPA protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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