| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.29ng/mL |
| Detection Limit: |
0.781-50ng/mL |
| Short Description: |
This PNPLA3 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
PNPLA3 |
| Gene ID: |
80339 |
| Uniprot ID: |
PLPL3_HUMAN |
| Sample Type: |
tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | |
| Function | Specifically catalyzes coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids. Does not esterify other lysophospholipids. Acyl donors are long chain (at least C16) fatty acyl-CoAs: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA and at a lesser extent palmitoyl-CoA. Additionally possesses low triacylglycerol lipase and CoA-independent acylglycerol transacylase activities and thus may play a role in acyl-chain remodeling of triglycerides. In vitro may express hydrolytic activity against glycerolipids triacylglycerol, diacylglycerol and monoacylglycerol, with a strong preference for oleic acid as the acyl moiety. However, the triacylglycerol hydrolase activity is controversial and may be very low. Possesses phospholipase A2 activity. |
| Protein Name | 1-Acylglycerol-3-Phosphate O-Acyltransferase Pnpla3Acylglycerol TransacylaseAdiponutrinAdpnCalcium-Independent Phospholipase A2-EpsilonIpla2-EpsilonLysophosphatidic Acid AcyltransferasePatatin-Like Phospholipase Domain-Containing Protein 3 |
| Database Links | Reactome: R-HSA-1482883 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane ProteinLipid Droplet |
| Alternative ELISA Names | 1-Acylglycerol-3-Phosphate O-Acyltransferase Pnpla3 ELISA kitAcylglycerol Transacylase ELISA kitAdiponutrin ELISA kitAdpn ELISA kitCalcium-Independent Phospholipase A2-Epsilon ELISA kitIpla2-Epsilon ELISA kitLysophosphatidic Acid Acyltransferase ELISA kitPatatin-Like Phospholipase Domain-Containing Protein 3 ELISA kitPNPLA3 ELISA kitADPN ELISA kitC22orf20 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
