| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.06ng/mL |
| Detection Limit: |
0.156-10ng/mL |
| Short Description: |
This PKCb1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
3 hrs |
| Gene Symbol: |
ZMYND8 |
| Gene ID: |
23613 |
| Uniprot ID: |
ZMYD8_HUMAN |
| Immunogen Region: |
Ready-To-Use |
| Sample Type: |
serum, plasma, tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | Expressed in neurons (at protein level). Absent in astrocytes (at protein level). Expressed in all tissues examined with highest expression in brain, lung, pancreas, and placenta. Expressed in cutaneous T-cell lymphomas (CTCL). |
| Post Translational Modifications | |
| Function | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac. May also act as a transcriptional corepressor for KDM5C and EZH2. Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination. Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters. Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression. Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform. Suppresses breast cancer, and prostate cancer cell invasion and metastasis. |
| Protein Name | Mynd-Type Zinc Finger-Containing Chromatin Reader Zmynd8Cutaneous T-Cell Lymphoma-Associated Antigen Se14-3Ctcl-Associated Antigen Se14-3Protein Kinase C-Binding Protein 1Rack7Transcription Coregulator Zmynd8Zinc Finger Mynd Domain-Containing Protein 8 |
| Database Links | |
| Cellular Localisation | NucleusChromosomeCytoplasmSequestered In The Cytoplasm Through The Interaction With Dbn1Localizes To Sites Of Dna Damage In A Kat5-Dependent And Dna Poly (Adp-Ribose)-Dependent MannerOn ChromatinLocalizes To Demethylated RegionsActive PromotersAnd Transcription Start Sites |
| Alternative ELISA Names | Mynd-Type Zinc Finger-Containing Chromatin Reader Zmynd8 ELISA kitCutaneous T-Cell Lymphoma-Associated Antigen Se14-3 ELISA kitCtcl-Associated Antigen Se14-3 ELISA kitProtein Kinase C-Binding Protein 1 ELISA kitRack7 ELISA kitTranscription Coregulator Zmynd8 ELISA kitZinc Finger Mynd Domain-Containing Protein 8 ELISA kitZMYND8 ELISA kitKIAA1125 ELISA kitPRKCBP1 ELISA kitRACK7 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
