• Human PDE3A (Phosphodiesterase 3A, cGMP Inhibited) Sandwich ELISA Kit Ready-To-Use (STJE0017727)

Human PDE3A (Phosphodiesterase 3A, cGMP Inhibited) Sandwich ELISA Kit Ready-To-Use (STJE0017727)

SKU:
STJE0017727

£481.50 - £659.50
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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.101ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This PDE3A Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: PDE3A
Gene ID: 5139
Uniprot ID: PDE3A_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity
Post Translational Modifications
Function Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has also activity toward cUMP. Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling.
Protein Name Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3a
Cyclic Gmp-Inhibited Phosphodiesterase A
Cgi-Pde A
Cgmp-Inhibited Camp Phosphodiesterase
Cgi-Pde
Database Links Reactome: R-HSA-418555
Cellular Localisation Membrane
Multi-Pass Membrane Protein
Cytoplasm
Cytosol
Alternative ELISA Names Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3a ELISA kit
Cyclic Gmp-Inhibited Phosphodiesterase A ELISA kit
Cgi-Pde A ELISA kit
Cgmp-Inhibited Camp Phosphodiesterase ELISA kit
Cgi-Pde ELISA kit
PDE3A ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance