• Human NGF (NGF) Sandwich ELISA Kit (STJE0000081)

Human NGF (NGF) Sandwich ELISA Kit (STJE0000081)

SKU:
STJE0000081-96

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 4.2 pg/mL
Detection Limit: 156-1000 pg/ml
Short Description: This NGF Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Conjugation: Biotin
Storage Instruction: Unopened kits can be stored at 2-8°C for 1 year, and opened products must be used within 1 month.
Assay Time: 4 hours
Detection: Colorimetric
Gene Symbol: NGF
Gene ID: 4803
Uniprot ID: NGF_HUMAN
Sample Type: serum, plasma and cell culture supernates
Tissue Specificity
Post Translational Modifications
Function Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (Probable). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI. Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form.
Protein Name Beta-Nerve Growth Factor
Beta-Ngf
Database Links Reactome: R-HSA-167021
Reactome: R-HSA-167044
Reactome: R-HSA-167060
Reactome: R-HSA-170968
Reactome: R-HSA-170984
Reactome: R-HSA-177504
Reactome: R-HSA-187042
Reactome: R-HSA-187706
Reactome: R-HSA-193648
Reactome: R-HSA-193670
Reactome: R-HSA-193681
Reactome: R-HSA-198203
Reactome: R-HSA-198745
Reactome: R-HSA-205017
Reactome: R-HSA-205025
Reactome: R-HSA-205043
Reactome: R-HSA-209543
Reactome: R-HSA-209560
Reactome: R-HSA-209563
Cellular Localisation Secreted
Endosome Lumen
Prongf Is Endocytosed After Binding To The Cell Surface Receptor Formed By Sort1 And Ngfr
Alternative ELISA Names Beta-Nerve Growth Factor ELISA kit
Beta-Ngf ELISA kit
NGF ELISA kit
NGFB ELISA kit
output

Information sourced from Uniprot.org

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