• Human NEIL1 (Nei Endonuclease VIII Like Protein 1) Sandwich ELISA Kit (STJE0010911)

Human NEIL1 (Nei Endonuclease VIII Like Protein 1) Sandwich ELISA Kit (STJE0010911)

SKU:
STJE0010911

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.062ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This NEIL1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: NEIL1
Gene ID: 79661
Uniprot ID: NEIL1_HUMAN
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Ubiquitous.
Post Translational Modifications
Function Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
Protein Name Endonuclease 8-Like 1
Dna Glycosylase/Ap Lyase Neil1
Dna-(Apurinic Or Apyrimidinic Site Lyase Neil1
Endonuclease Viii-Like 1
Fpg1
Nei Homolog 1
Neh1
Nei-Like Protein 1
Database Links Reactome: R-HSA-110328
Reactome: R-HSA-110329
Reactome: R-HSA-5649702
Reactome: R-HSA-9616334
Cellular Localisation Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Nucleus
Chromosome
During Mitosis
Associates With Centrosomes And Condensed Chromatin
Alternative ELISA Names Endonuclease 8-Like 1 ELISA kit
Dna Glycosylase/Ap Lyase Neil1 ELISA kit
Dna-(Apurinic Or Apyrimidinic Site Lyase Neil1 ELISA kit
Endonuclease Viii-Like 1 ELISA kit
Fpg1 ELISA kit
Nei Homolog 1 ELISA kit
Neh1 ELISA kit
Nei-Like Protein 1 ELISA kit
NEIL1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance