Human NEDD4L/Nedd4-2 protein (Recombinant) (N-His) (STJP006424)

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STJP006424
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human NEDD4L/Nedd4-2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: NEDD4L
Gene ID: 23327
Uniprot ID: NED4L_HUMAN
Immunogen Region: Glu629-Asp975
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated by SGK1 or PKA.which impairs interaction with SCNN. Interaction with YWHAH inhibits dephosphorylation. Auto-ubiquitinated. Deubiquitinated by USP36, no effect on NEDD4L protein levels. Both proteins interact and regulate each other's ubiquitination levels.
Function E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1. Plays a role in dendrite formation by melanocytes. Involved in the regulation of TOR signaling. Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF. Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3. Ubiquitinates TTYH2 and TTYH3 and regulates protein levels of TTYH2.
Protein Name E3 Ubiquitin-Protein Ligase Nedd4-Like
Hect-Type E3 Ubiquitin Transferase Ned4l
Nedd4.2
Nedd4-2
Database Links Reactome: R-HSA-162588
Reactome: R-HSA-2173788
Reactome: R-HSA-2173795
Reactome: R-HSA-2672351
Reactome: R-HSA-983168
Cellular Localisation Cytoplasm
Golgi Apparatus
Endosome
Multivesicular Body
May Be Recruited To Exosomes By Ndfip1
Alternative Protein Names E3 Ubiquitin-Protein Ligase Nedd4-Like protein
Hect-Type E3 Ubiquitin Transferase Ned4l protein
Nedd4.2 protein
Nedd4-2 protein
NEDD4L protein
KIAA0439 protein
NEDL3 protein

Information sourced from Uniprot.org

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