| Post Translational Modifications | Under stress conditions, phosphorylated in the C-terminal on many serine and threonine residues. Phosphorylated in vitro by PKA. Phosphorylation enhanced by increased intracellular cAMP levels. Homocysteine induces dephosphorylation. Phosphorylation by SGK1 is cell cycle dependent. |
| Function | Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy. |
| Protein Name | Protein Ndrg1Differentiation-Related Gene 1 ProteinDrg-1N-Myc Downstream-Regulated Gene 1 ProteinNickel-Specific Induction Protein Cap43Reducing Agents And Tunicamycin-Responsive ProteinRtpRit42 |
| Database Links | Reactome: R-HSA-6803205 |
| Cellular Localisation | CytoplasmCytosolCytoskeletonMicrotubule Organizing CenterCentrosomeNucleusCell MembraneMainly Cytoplasmic But Differentially Localized To Other RegionsAssociates With The Plasma Membrane In Intestinal Epithelia And Lactating Mammary GlandTranslocated To The Nucleus In A P53/Tp53-Dependent MannerIn Prostate Epithelium And Placental ChorionLocated In Both The Cytoplasm And In The NucleusNo Nuclear Localization In Colon Epithelium CellsIn Intestinal MucosaProstate And Renal CortexLocated Predominantly Adjacent To Adherens JunctionsCytoplasmic With Granular Staining In Proximal Tubular Cells Of The Kidney And Salivary Gland DuctsRecruits To The Membrane Of Recycling/Sorting And Late Endosomes Via Binding To Phosphatidylinositol 4-PhosphateAssociates With MicrotubulesColocalizes With Tubg1 In The CentrosomeCytoplasmic Location Increased With HypoxiaPhosphorylated Form Found Associated With Centromeres During S-Phase Of Mitosis And With The Plasma Membrane |
| Alternative Protein Names | Protein Ndrg1 proteinDifferentiation-Related Gene 1 Protein proteinDrg-1 proteinN-Myc Downstream-Regulated Gene 1 Protein proteinNickel-Specific Induction Protein Cap43 proteinReducing Agents And Tunicamycin-Responsive Protein proteinRtp proteinRit42 proteinNDRG1 proteinCAP43 proteinDRG1 proteinRTP protein |
Information sourced from Uniprot.org
