• Human MYO10 (Myosin X) Competitive ELISA Kit (STJE0010846)

Human MYO10 (Myosin X) Competitive ELISA Kit (STJE0010846)

SKU:
STJE0010846

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.114ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This MYO10 Competitive ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 2.5 hrs
Gene Symbol: MYO10
Gene ID: 4651
Uniprot ID: MYO10_HUMAN
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Ubiquitous.
Post Translational Modifications The initiator methionine for isoform Headless is removed.
Function Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as a plus end-directed motor. Moves with higher velocity and takes larger steps on actin bundles than on single actin filaments. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts. Isoform Headless: Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion.
Protein Name Unconventional Myosin-X
Unconventional Myosin-10
Database Links Reactome: R-HSA-2029482
Reactome: R-HSA-373752
Reactome: R-HSA-9664422
Cellular Localisation Cytoplasm
Cytosol
Cell Projection
Lamellipodium
Ruffle
Cytoskeleton
Filopodium Tip
Cell Cortex
Filopodium Membrane
Peripheral Membrane Protein
May Be In An Inactive
Monomeric Conformation In The Cytosol
Detected In Cytoplasmic Punctae And In Cell Projections
Colocalizes With Actin Fibers
Undergoes Forward And Rearward Movements Within Filopodia
Interacts With Microtubules
Alternative ELISA Names Unconventional Myosin-X ELISA kit
Unconventional Myosin-10 ELISA kit
MYO10 ELISA kit
KIAA0799 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance