• Human MR (Mineralocorticoid Receptor) Sandwich ELISA Kit Ready-To-Use (STJE0017110)

Human MR (Mineralocorticoid Receptor) Sandwich ELISA Kit Ready-To-Use (STJE0017110)

SKU:
STJE0017110

£443.50 - £605.50
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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.112ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This MR Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: NR3C2
Gene ID: 4306
Uniprot ID: MCR_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Ubiquitous. Highly expressed in distal tubules, convoluted tubules and cortical collecting duct in kidney, and in sweat glands. Detected at lower levels in cardiomyocytes, in epidermis and in colon enterocytes.
Post Translational Modifications Phosphorylated.
Function Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.
Protein Name Mineralocorticoid Receptor
Mr
Nuclear Receptor Subfamily 3 Group C Member 2
Database Links Reactome: R-HSA-3371497
Reactome: R-HSA-383280
Reactome: R-HSA-4090294
Cellular Localisation Cytoplasm
Nucleus
Endoplasmic Reticulum Membrane
Peripheral Membrane Protein
Cytoplasmic And Nuclear In The Absence Of Ligand
Nuclear After Ligand-Binding
When Bound To Hsd11b2
It Is Found Associated With The Endoplasmic Reticulum Membrane
Alternative ELISA Names Mineralocorticoid Receptor ELISA kit
Mr ELISA kit
Nuclear Receptor Subfamily 3 Group C Member 2 ELISA kit
NR3C2 ELISA kit
MCR ELISA kit
MLR ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance