Human MFSD8/CLN7 protein (Recombinant) (N-GST & C-His) (STJP008514)

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STJP008514
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human MFSD8/CLN7-N-GST & C-His protein was developed from e. coli and has a target region of N-GST & C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: MFSD8
Gene ID: 256471
Uniprot ID: MFSD8_HUMAN
Immunogen Region: Asn359-Pro412
Immunogen: Homo sapiens (Human)
Function Outward-rectifying chloride channel involved in endolysosomal chloride homeostasis, membrane fusion and function. Conducts chloride currents up to hundreds of picoamperes. Regulates lysosomal calcium content by reducing the lysosomal membrane potential, thereby activating TRPML1 channel and further release of lysosomal calcium ions. Regulates the pH in endolysosomal compartments and may contribute to progressive acidification from endosome to lysosome. Permeable to other halides such as iodide and fluoride ions.
Protein Name Major Facilitator Superfamily Domain-Containing Protein 8
Ceroid-Lipofuscinosis Neuronal Protein 7
Cellular Localisation Endosome Membrane
Multi-Pass Membrane Protein
Lysosome Membrane
Sorting To Lysosomes Involves Dileucine-Based Motif
Alternative Protein Names Major Facilitator Superfamily Domain-Containing Protein 8 protein
Ceroid-Lipofuscinosis Neuronal Protein 7 protein
MFSD8 protein
CLN7 protein

Information sourced from Uniprot.org

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