| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.114ng/mL |
| Detection Limit: |
0.312-20ng/mL |
| Short Description: |
This MFSD2A Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
MFSD2A |
| Gene ID: |
84879 |
| Uniprot ID: |
NLS1_HUMAN |
| Sample Type: |
tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | In placenta, associated with trophoblast cells. |
| Post Translational Modifications | |
| Function | Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons. Does not transport docosahexaenoic acid in unesterified fatty acid. Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport. Not required for central nervous system vascular morphogenesis. Acts as a transporter for tunicamycin, an inhibitor of asparagine-linked glycosylation. In placenta, acts as a receptor for ERVFRD-1/syncytin-2 and is required for trophoblast fusion. |
| Protein Name | Sodium-Dependent Lysophosphatidylcholine Symporter 1Nls1Sodium-Dependent Lpc Symporter 1Major Facilitator Superfamily Domain-Containing Protein 2aHsmfsd2aMfsd2a |
| Database Links | Reactome: R-HSA-1483191 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum MembraneCytoplasmic Punctae That May Represent Vesicles Shuttling Between The Endoplasmic Reticulum And The Plasma Membrane |
| Alternative ELISA Names | Sodium-Dependent Lysophosphatidylcholine Symporter 1 ELISA kitNls1 ELISA kitSodium-Dependent Lpc Symporter 1 ELISA kitMajor Facilitator Superfamily Domain-Containing Protein 2a ELISA kitHsmfsd2a ELISA kitMfsd2a ELISA kitMFSD2A ELISA kitMFSD2 ELISA kitNLS1 ELISA kitHMFN0656 ELISA kitPP9177 ELISA kitUNQ300 ELISA kitPRO341 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
